Synthesis of Seven-Membered-Ring Ketones by Arylative Ring Expansion of Alkyne-Substituted Cyclobutanones

✍ Scribed by Takanori Matsuda; Masaomi Makino; Masahiro Murakami

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 317 KB
• Volume: 44
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200500799

✦ Synopsis

Medium-sized carbocyclic ring systems are often present as the structural core in natural products of interesting biological activities. Thus, the development of new synthetic methods for medium-sized carbocyclic rings has been one of the prime targets in organic synthesis. [1] Fragmentation of an easily accessible bicyclic system circumvents unfavorable enthalpic and entropic factors associated with direct formation of the medium-sized ring by annulation or cyclization. [2] A number