𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of sequential polypeptides containing L-β-3,4-dihydroxyphenyl-α-alanine (DOPA) and L-lysine

✍ Scribed by Hiroyuki Yamamoto; Tadao Hayakawa

Publisher
Wiley (John Wiley & Sons)
Year
1982
Tongue
English
Weight
781 KB
Volume
21
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Six different sequential polypeptides with the repeating units L‐lysyl‐L‐DOPA, L‐DOPA‐L‐lysine, L‐lysyl‐L‐lysyl‐L‐DOPA, L‐DOPA‐L‐DOPA‐L‐lysine, L‐lysyl‐L‐lysyl‐L‐lysyl‐L‐DOPA, and L‐DOPA‐L‐DOPA‐L‐DOPA‐L‐lysine have been synthesized by solution polymerization of the p‐nitrophyenyl esters of the corresponding di‐, tri‐, and tetrapeptides. The O,O′‐dimethyl and N‐ε‐2‐chlorobenzyloxycarbonyl groups were used to protect side chains of L‐DOPA and L‐lysine. The monomers for the polytripeptides and polytetrapeptides were prepared by stepwise elongation, using the dicyclohexylcarbodiimide coupling method. Moderately high molecular weight sequential polypeptides were obtained. The addition of 1‐hydroxybenzotriazole increased their molecular weights, but not so effectively. The protected groups of the side chains were removed simultaneously by use of boron tribromide in chloroform. Water‐soluble sequential polypeptides containing L‐DOPA were obtained.

📜 SIMILAR VOLUMES

Synthesis of sequential polypeptides con
Synthesis of sequential polypeptides containing L-β-3,4-dihydroxyphenyl-α-alanine (DOPA) and L-glutamic acid
✍ Hiroyuki Yamamoto; Tadao Hayakawa 📂 Article 📅 1979 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 551 KB

## Abstract Sequential polypeptides with the repeating units L‐glutamyl‐L‐DOPA, L‐DOPA‐L‐glutamyl‐L‐DOPA, L‐glutamyl‐L‐glutamyl‐L‐DOPA, L‐DOPA‐L‐DOPA‐L‐glutamyl‐L‐DOPA, and L‐glutamyl‐L‐glutamyl‐L‐glutamyl‐L‐DOPA have been synthesized by solution polymerization of the __p__‐nitrophenyl esters of th

Facile Synthesis of L-3-(3,4-Dihydroxyph
Facile Synthesis of L-3-(3,4-Dihydroxyphenyl)alanine (L-Dopa) and Related Compounds
✍ Dr. E.-O. Renth 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB 👁 2 views

Isomerization was performed by refluxing solutions of ( 3 j -( 7 ) (5mmol) in 2.0M (12.51111) ethereal zinc iodide solution for 2-4 h. The isomerizations can also be carried out on a preparative scale:

Synthesis and conformational study of po
Synthesis and conformational study of poly(0,0′-dicarbobenzoxy-L-β-3,4-dihydroxyphenyl-α-alanine)
✍ Hiroyuki Yamamoto; Tadao Hayakawa 📂 Article 📅 1977 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 618 KB

## Abstract High‐molecular‐weight poly(0,0′‐dicarbobenzoxy‐L‐β‐3,4‐dihydroxyphenyl‐α‐alanine) was prepared by the __N__‐carboxyanhydride method. From the results obtained by a study of the optical rotation, nuclear magnetic resonance, and solution infrared absorption, the conformation of poly(0,0′‐