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Synthesis of selectively 13C-labelled benzoic acid for nuclear magnetic resonance spectroscopic measurement of glycine conjugation activity

✍ Scribed by Kazuki Akira; Hiroshi Hasegawa; Shigeo Baba

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
435 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of [4‐^13^C]benzoic acid (BA) labelled in a single protonated carbon, for use as a probe to measure glycine conjugation activity by nuclear magnetic resonance (NMR) spectroscopy, has been reported. The labelled compound was prepared by a seven‐step synthetic scheme on a relatively small scale using [2‐^13^C]acetone as the source of label in overall yield of 16 %. The usefulness of [4‐^13^C]BA was demonstrated by the NMR spectroscopic monitoring of urinary excretion of [4‐^13^C]hippuric acid in the rat administered with the labelled BA.

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