Synthesis of (S)-2-Boc-Amino-8-(R)-(tert-butyldimethylsilanyloxy)decanoic acid, a precursor to the unusual amino acid residue of the anticancer agent microsporin B

Application of the gold(I)-Catalyzed ald

Application of the gold(I)-Catalyzed aldol reaction to a stereoselective synthesis of (2S, 3R, 4R, 6E)-3-Hydroxy-4-methyl-2-(methylamino)oct-6-enoic Acid ( = MeBmt), Cyclosporin's unusual amino acid

✍ Antonio Togni; Stephen D. Pastor; Grety Rihs 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 German ⚖ 507 KB

Introduction. ~ Stereoselective C-C bond forming reactions catalyzed by chiral transition-metal complexes are a topic of fundamental importance [l]. In 1986, Hayashi and Zto reported an elegant asymmetric synthesis of dihydrooxazoles by an efficient gold(1)-catalyzed coupling of aldehydes with 2-iso