✦ LIBER ✦

Synthesis of radioiodo-[4-(2-iodo-4-fluoro-benzoyl)piperidin-1-yl]-2′-acetonaphthone

✍ Scribed by J. Mertens; M. Thomas

Book ID: 102375743
Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 202 KB
Volume: 29
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580290814

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✦ Synopsis

Abstract

Radioiodo‐[4‐(2‐1‐4‐fluorobenzoyl)piperidin‐1‐yl]‐2′‐acetonaphthone was synthesised as a potential in vivo tracer of the glutamate release inhibiting system. The labeling was performed by Cu^1+^ assisted non isotopic nucleophilic exchange on [4‐(2‐bromo‐4‐fluorobenzoyl)piperidin‐1‐yl]‐2′‐acetonaphthone.

The labeled compound is obtained after HPLC separation and mini‐column recovery. The brominated substrate is obtained by Kl catalyzed coupling of 2‐bromo‐acetonaphthone to the piperidinyl entity in ethanol at room temperature using triethylamine.

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