Synthesis of radioactive tributyl[113Sn]tin of high specific activity for use in environmental fate studies
✍ Scribed by Claude Rouleau
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 394 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0268-2605
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✦ Synopsis
A method of synthesis of tributyl[ 113 Sn]tin, (n/C 4 H 9 ) 3 113 Sn(IV), from commercially available inorganic 113 Sn(IV) is presented. Inorganic tin is first extracted in diethyl ether and reacted with C 4 H 9 MgCl to produce tetrabutyltin, (C 4 H 9 ) 4 113 Sn, which is then debutylated with HgCl 2 . The resulting tributyl[ 113 Sn]tin chloride is isolated from the reaction mixture by successive extractions with hexane and aqueous Na 2 S 2 O 3 . The yield is 40-60% and the product obtained is b98% pure. It has the same specific activity as the starting 113 Sn(IV), i.e. up to 550 MBq mg À1 Sn, making it suitable for use in environmental fate and toxicology studies at concentrations relevant of those found in the aquatic environment.