Synthesis of (R)-N-[4-[4-(dibutylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (artilide fumarate) and the enantiomers of N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (ibutilide fumarate)
โ Scribed by Sam C. Perricone; Constance G. Chidester; Jackson B. Hester
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 956 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
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๐ SIMILAR VOLUMES
We had previously demonstrated the utility of N-vinylpyridinium tetrafluoroborate salts as novel electrophilic coupling partners in Pd(0)-catalyzed Suzuki cross-coupling reactions with aryl and vinyl boronic acids. We now report that these crystalline, air-stable, and non-hygroscopic salts are also
## Abstract magnified image 5โArylโ6__H__โ1,3,4โthiadiazinโ2โaminium and 5โarylโ__N__โphenylโ6__H__โ1,3,4โthiadiazinโ2โaminium salts have efficiently been synthesized from the reaction of thiosemicarbazide and ฮฑโhaloketones in acetonitrile at room temperature using i) silica supported sodium hydro