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Synthesis of ( R )-(4-Methoxy-3,5-dihydroxyphenyl)glycine Derivatives: The Central Amino Acid of Vancomycin and Related Agents

โœ Scribed by Boger, Dale L.; Borzilleri, Robert M.; Nukui, Seiji


Book ID
126978551
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
246 KB
Volume
61
Category
Article
ISSN
0022-3263

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โœ Dieter Seebach; Matthias Hoffmann ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 612 KB

The title compound BDI is prepared on multigram scale, so clean that highly efficient in-situ double alkylations are feasible, in which the sequence of addition of the two either by resolution of the precursor 2-tert-butylimidazolidin-4-one (from glycine amide and pivalaldehyde) through different el