A Simple Stereoselective Synthesis of En
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José M. Andrés; Ignacio Herráiz-Sierra; Rafael Pedrosa; Alfonso Pérez-Encabo
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Article
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2000
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John Wiley and Sons
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English
⚖ 319 KB
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Chiral, nonracemic 2-substituted pyrrolidines and piperidines were prepared in high ee and moderate to good chemical yields in three steps from (R)-phenylglycinol and γ-or δchloroketones. The key step of the synthesis was the stereo-