Synthesis of pyrimido[6,1-a]isoquinolines via a one-pot, four-component reaction
β Scribed by Abdolali Alizadeh; Atieh Rezvanian; Log-Guan Zhu
- Book ID
- 108283351
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 475 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0040-4020
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## Abstract A fourβcomponent reaction for the synthesis of 1,2βdihydroisoquinoline derivatives is described. The __Huisgen__ 1,4βdipolar intermediate, which is produced from isoquinoline and an electronβdeficient acetylene compound **1**, reacts with H~2~O in the presence of diketene to produce 1,2
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