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Synthesis of Pyridinium Amphiphiles Used for Transfection and Some Characteristics of Amphiphile/DNA Complex Formation

✍ Scribed by Arthur A. P. Meekel; Anno Wagenaar; Jarmila Šmisterová; Jessica E. Kroeze; Peter Haadsma; Bouke Bosgraaf; Marc C. A. Stuart; Alain Brisson; Marcel H. J. Ruiters; Dick Hoekstra; Jan B. F. N. Engberts

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 778 KB
Volume: 2000
Category: Article
ISSN: 1434-193X
DOI: 10.1002/(sici)1099-0690(200002)2000:4<665::aid-ejoc665>3.0.co;2-a

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✦ Synopsis

Pyridinium amphiphiles have found practical use for the delivery of DNA into cells. Starting from 4-methylpyridine, a general synthesis has been devised for the production of pyridinium amphiphiles which allows variation in both the hydrophobic part and in the headgroup area of the compounds.

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