𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of Pyrazolo Heteroaromatic Compounds by Means of 5-Amino-3-methyl-1-phenylpyrazole-4-carbaldehyde

✍ Scribed by Dipl.-Chem. Jochen Häufel; Prof. Dr. Eberhard Breitmaier

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
128 KB
Volume
13
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.

✦ Synopsis

composition, and IR spectrumi3] with the product prepared from SOClz and HzS,. This new, more productive synthetic route requires much less time and experimental effort than the former preparation.

Procedtwe:

Sg (3.76g, 14.7mmol)isdissolved in CHzC12 (800ml) by refluxing. The homogeneous solution is slowly cooled to 0°C and protected from light by a black cloth. A freshly prepared solution of trifluoroperacetic acid [obtained by suspension of 50% H r 0 2 ( l g , 14.7mmol) in CH2C12 (50ml) at 0°C and rapid addition of trifluoroacetic anhydride ( 5 ml, 36mniol)l is added dropwise over 1 h to the stirred reaction mixture, which assumes an intense yellow hue. Concentration in a vacuum at 20°C bath temperature to 1/3 of the original volume leads to precipitation. Further crystallization is induced by cooling to -20°C. The precipitate is collected on a glass frit, washed with CHzC12, and dried in a vacuum. The procedure yields 1.8g of almost pure S 8 0 which can be isolated analytically pure by recrystallization from CS2.

📜 SIMILAR VOLUMES

Synthesis and Glycosidase Inhibitory Act
Synthesis and Glycosidase Inhibitory Activity of Five Stereoisomers of 5-Amino-5-C-methyl-1,2,3,4-cyclopentanetetrol
✍ Seiichiro Ogawa; Kenji Washida 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB 👁 1 views

In order to elucidate the essential core structure of potent the five stereoisomers thus obtained for the six glycosidases has demonstrated the 2/3,4,5) and (1,2,3,4,5/0) isomers α-mannosidase inhibitors, e.g. mannostatin A, 5-amino-5-Cmethyl-1,2,3,4-cyclopentanetetrols 4-8 were designed and to be m