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Synthesis of pyrazolo-fused heterocycles by a tandem appel's dehydration/electrocyclization methodology

โœ Scribed by Kee-Jung Lee; Heung-Taeck Kwon; Boo-Geun Kim


Book ID
102338384
Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
320 KB
Volume
34
Category
Article
ISSN
0022-152X

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## Abstract A twoโ€step diastereoselective synthesis of linearโ€fused tricyclic nitrogen heterocycles has been developed from cyclic ฮฒโ€ketoesters. The cyclization substrates are readily prepared by alkylation of the methyl 2โ€oxoโ€cycloalkanecarboxylates with 2โ€nitrobenzyl bromide. Hydrogenation of the