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Synthesis of prumycin and related compounds

✍ Scribed by Akira Hasegawa; Nobumitsu Aritake; Makoto Kiso

Book ID
108308857
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
892 KB
Volume
52
Category
Article
ISSN
0008-6215

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πŸ“œ SIMILAR VOLUMES

Synthesis of prumycin
Synthesis of prumycin
✍ Hiroyoshi Kuzuhara; Sakae Emoto πŸ“‚ Article πŸ“… 1975 πŸ› Elsevier Science 🌐 French βš– 230 KB

Prumycin is a new antifungal antibiotic isolated as a dihydrochloride by Hata et al. 1) in 1971. It strongly inhibits the growth of phytopathogenic fungi such as Scterotinia sclerothrwn and Botorytis fabae. The structure of prumycin was recently elucidated to be 4-D- alanylamino-2-amino-2.4-dideoxy-

Synthesis and Antifungal Activity of 3-D
Synthesis and Antifungal Activity of 3-Deoxy-DL-prumycin Analogues
✍ Constantinou-Kokotou, Violetta ;Kokotos, George ;Chrysayi-Tokousbalides, Maria ; πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 373 KB

## Abstract A number of 3‐deoxy‐DL‐prumycin analogues containing one or more amino acid moieties were synthesized. Key intermediate 2 afforded ester analogues by coupling with H‐D‐ or L‐Ala‐OH, while intermediates 6 and 9 afforded amide analogues by coupling with H‐D‐Ala‐D‐Ala‐OH, H‐D‐Ala‐OH, 2‐ami