Synthesis of (Pro-Hyp-Gly)n of defined molecular weights Evidence for the stabilization of collagen triple helix by hydroxypyroline

Synthesis of poly(Pro–Hyp–Gly)n by direc

Synthesis of poly(Pro–Hyp–Gly)n by direct polycondensation of (Pro–Hyp–Gly)n, where n = 1, 5, and 10, and stability of the triple-helical structure

✍ Takahiro Kishimoto; Yasushi Morihara; Michinori Osanai; Shin-ichi Ogata; Masanob 📂 Article 📅 2005 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 566 KB

## Abstract Pro–Hyp–Gly is a characteristic amino acid sequence found in fibrous collagens, and (Pro–Hyp–Gly)~10~, which has been widely used as a collagen‐model peptide, forms a stable triple‐helical structure. Here, we synthesized polypeptides consisting of the Pro–Hyp–Gly sequence by direct poly