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Synthesis of pppA2′p5′A2′p5′A γ-amidates by one pot procedure from A2′p5′A2′p5′A

✍ Scribed by Ágnes Nyilas

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
269 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

One pot synthesis of prnidate of pppA2'p5'A2'p5'A described here using phosphoroxychloride and bis-tri-n-butylammonium pyrophosphate for preparing cyclic trimetaphosphate intermediate opening up with n-decylamin. 01997 Elsevier ScienceLtd.

The 5'-phosphorylation of 2',5'A analogues helps them to bind to endoribonuclease', but a phosphataae degrades it. Therefore it is important to synthesize phosphatase resistant analoguesz. Altough

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