𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of potential metabolites of the brain imaging agents methyl (1R,2S,3S,5S)-3-(4-Iodophenyl)-8-alkyl-8-azabicyclo[3.2.1]octane-2-carboxylate

✍ Scribed by Annette Andersen; Shaoyin Wang; Robert D. Thompson; John L. Neumeyer

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
305 KB
Volume
34
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis of potential hydroxy metabolites of the brain imaging agents methyl (1__R__,2__S__,3__S__,5__S__)‐3‐(4‐iodophenyl)‐8‐methyl‐8‐azabicyclo[3.2.1]octane‐2‐carboxylate and methyl (1__R__,2__S__,3__S__,5__S__)‐3‐(4‐iodophenyl)‐8‐(3‐fluoropropyl)‐8‐azabicyclo[3.2.1]octane‐2‐carboxylate are reported. The nitration of iodophenyltropanes 1 or 2 with nitronium tetrafluoroborate afforded the nitro compounds 3 or 4 which were reduced with iron powder to the corresponding amino compounds 5 and 6. The final hydroxylated products 7 and 8 were obtained via a modified Sandmeyer reaction.

📜 SIMILAR VOLUMES

Diastereoselective Reaction of (1S,2S)-2
Diastereoselective Reaction of (1S,2S)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol with Aromatic Aldehydes. Synthesis of (1R,2R,4S,5S,8S)-2,8-Diaryl-4-(4-nitrophenyl)-1-aza-3,7-dioxabicyclo [3.3.0]octanes.
✍ M. Madesclaire; P. Coudert; V. Gaumet; V. P. Zaitsev; Yu. V. Zaitseva 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 24 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.