Synthesis of Polyfunctional Aromatic Ring Systems (Phloroglucide Analogs) under Microwave Irradiation

✍ Scribed by Ali Khalafi-Nezhad; Mohammad Navid Soltani Rad; Gholam Hossein Hakimelahi

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: German
• Weight: 91 KB
• Volume: 86
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200390192

✦ Synopsis

Abstract

An efficient and rapid synthesis of phloroglucide analogs under microwave irradiation is described. The solid‐phase condensation reaction of the 4‐halo‐2,6‐bis(hydroxymethyl)phenols 1a,b with other substituted phenols in the presence of ZnCl~2~ afforded the target molecules in much higher yields than by classical solution‐phase synthesis and allowed us to prepare new phloroglucide analogs possessing sensitive functional groups difficult to access by established means.