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Synthesis of polyether-bound 3-(5-fluorouracil-1-yl)propanoic acid and its hydrolysis reactivity

✍ Scribed by T. Ouchi; H. Yuyama; T. Inui; H. Murakami; H. Fujie; O. Vogi

Book ID: 103072863
Publisher: Elsevier Science
Year: 1986
Tongue: English
Weight: 266 KB
Volume: 22
Category: Article
ISSN: 0014-3057
DOI: 10.1016/0014-3057(86)90180-1

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✦ Synopsis

As a study on the synthesis of polymer for fixing 5-fluorouracil (5-FU), the synthesis of polyether-bound 3-(5-fluorouracil-l-yl)propanoic acid (4) through ester bonds was carried out. For investigation of the release of 5-FU residue from 4, the enzymatic and non-enzymatic hydrolyses of the pendant ester bonds in particular polyethers were investigated itt vitro.

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