Abstract
The polymerization of metal salts of N‐chloroacetyl‐β‐alanine and N‐chloroacetyl‐4‐aminobutyric acid was investigated. The former gives a mixture of polymer and a seven‐membered cyclic compound constituted of glycolic and β‐alanine units, and its reaction proceeds in the solid state. However, liquefaction is observed in the second case giving rise to a polymer with a moderate molecular weight. Condensation kinetics of both sodium and silver salts of N‐chloroacetyl‐β‐alanine have been studied by differential scanning calorimetry. Copolymers of glycolic acid and β‐alanine with a molar ratio of glycolic acid/β‐alanine varying from 0.5 to 1.0 have been synthesized by thermal reaction of co‐precipitated crystals of the sodium salts of chloroacetic acid and N‐chloroacetyl‐β‐alanine. NMR spectroscopy indicates that copolymers tend to have a random distribution. The resulting new poly(ester amide)s have been characterized by spectroscopy and thermal analysis.
DSC heating runs corresponding to different mixtures of the sodium salts of chloroacetic acid and chloroacetyl‐β‐alanine.
magnified imageDSC heating runs corresponding to different mixtures of the sodium salts of chloroacetic acid and chloroacetyl‐β‐alanine.