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Synthesis of Polyelectrolytes Bearing Phosphorylcholine Moieties

✍ Scribed by Andreas Reisch; Jean-Claude Voegel; Gero Decher; Pierre Schaaf; Philippe J. Mésini

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
170 KB
Volume
28
Category
Article
ISSN
1022-1336

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✦ Synopsis

Abstract

We report on the modification of the polyelectrolytes poly(L‐glutamic acid) (PGA), poly(acrylic acid) (PAA), and poly(L‐lysine) (PLL) with side groups bearing phosphorylcholine (PC) groups. Two different side chains were synthesized from monoamino tri‐ or tetraethylene glycol, both with PC group linked to the OH end: the tert‐butyloxycarbonyl protected compounds BOCNH(EO)~n~PC (n = 2, 3) and the succinylated compound SucNH(EO)~3~PC. BOCNH(EO)~n~PC was deprotected and the resulting amine was condensed with PGA or PAA and SucNH(EO)~3~PC was directly coupled to PLL. Degrees of substitution as high as 80% were obtained with the method described. These polyelectrolytes are potential candidates to fabricate multilayers with protein repellent properties.

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