Synthesis of piperazinones and benzopiperazinones from 1,2-diamines and organoboronic acids

✍ Scribed by Nicos A Petasis; Zubin D Patel

• Book ID: 104211264
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 114 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01717-2

✦ Synopsis

Alkenyl, aryl and heteroaryl boronic acids react with 1,2-diamines and glyoxylic acid to give directly in one step the corresponding piperazinones (2-oxopiperazines). Similarly, the use of monoprotected 1,2-phenylenediamine leads to benzopiperazinones (1,2,3,4-tetrahydroquinoxalin-2-ones).