Synthesis of phthalideisoquinolines from 3-halophthamdes and 3,4-dihydroisoquinolinium salts
β Scribed by Slemon, Clarke E.; Hellwig, Louise C.; Ruder, Jean-Pierre; Hoskins, Eric W.; MacLean, David B.
- Book ID
- 118164249
- Publisher
- NRC Research Press
- Year
- 1981
- Tongue
- French
- Weight
- 289 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0008-4042
- DOI
- 10.1139/v81-447
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π SIMILAR VOLUMES
NucleophiLic acylation of 3,44ihydroisoquinoliniinolinium salts 3 with lithiated enol ethers 6, 7, and 8 or vinyl sulfides 14 leads to the adducts 4 9 , and 16, mpctively, in mostly excellent yields. Hydrolysis of 4 alTords 94-97% of the ketones 5, which are transformed by treatment with conc. hydro
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