Synthesis of phosphotyrosine-containing peptides using bis-(2, 2, 2-trichloro)ethyl groups for phosphate protection
β Scribed by PAQUET, ALENKA ;BLACKWELL, BARBARA ;JOHNS, MICHAEL ;NIKIFORUK, JOHN
- Book ID
- 110893630
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 563 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1397-002X
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The utility of the 2-(arylcarbamoyloxy)ethyl group for protection of internucleosidic phosphate linkages in oligonucleotide synthesis was studied. Of the three protecting groups tested, the 2-[(1-naphthyl)carbamoyloxy]ethyl demonstrated high coupling yields, favorable deprotection kinetics and the h