Synthesis of phosphonate derivatives of 2,3-dihydroindene
✍ Scribed by Monika Prokopowicz; Piotr Młynarz; Paweł Kafarski
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 235 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Simple and convenient procedures for the synthesis of derivatives of 2,3-dihydroinden-2-ylphosphonic acid are developed. The reaction strategies utilize both functionalization of the already existing 2,3-dihydroindene skeleton and an annulation reaction starting from readily available o-disubstituted benzene derivatives.
📜 SIMILAR VOLUMES
A series of homologous racemic β-hydroxyaldehydes bearing a phosphonate group in the ω-position were synthesised and allowed to react with dihydroxyacetone phosphate (DHAP) via an enzymatic aldol addition catalysed by fructose 1,6-bisphosphate aldolase (FruA). After enzymatic dephosphorylation, a se