Synthesis of phosphonate analogues of myo-inositol phospholipids
β Scribed by C.E. Dreef; C.J.J. Elie; G.A. van der Marel; J.H. van Boom
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 293 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The racemlc 5phosphonate analogues IV and V of myuinosltol 1,4,5trrsphosphate were readily accessible by btsphosphorylatlon of the common precursor 6, removal of the pmethoxybenzyl group, phosphonylabon and subsequent hydrogenolysls of the benzyl protectmg groups The methylphosphonate analogue IV ac
(+/-)-2,3,6-Tri-O-benzyl-5-O-p-methoxybenzyl-myo-inositol and (+/-)-2,6-di-O-benzyl-5-O-p-methoxy-benzyl-myo-inositol, accessible readily from (+/-)-3,6-di-O-allyl-1,2-O-cyclohexylidene-myo-inositol, were phosphitylated with dibenzyl N,N-di-isopropylphosphoramidite, and the resulting phosphite tries
myo-Inositol 1,4,6-u-&phosphate, in optically inactive and active forms, was prepared in order to compare its biological activity with that of myo-inositol 1,3,4,6-tetrakisphosphate which releases Ca2+ from an intracellular store.