Synthesis of phenylalkyl-substituted polyhydroxypiperidines as potent inhibitors for α-l-fucosidase
✍ Scribed by Saka, Tomoki; Okaki, Toru; Ifuku, Shohei; Yamashita, Yukiko; Sato, Kasumi; Miyawaki, Shota; Kamori, Akiko; Kato, Atsushi; Adachi, Isao; Tezuka, Yasuhiro; Kiria, Peter G.; Onomura, Osamu; Minato, Daishiro; Sugimoto, Kenji; Matsuya, Yuji; Toyooka, Naoki
- Book ID
- 122850488
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- French
- Weight
- 620 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0040-4020
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-alpha production. We focused on the 1,1-substituted moiety (R(1) and R(2)) of SA13353 and investigated substituent effects of this moiety on LPS-induced TNF-a