Synthesis of 3-phenyl-5-(trifluoromethyl
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James W. Pavlik; Jennifer A. Lowell; Vuthichai Ervithayasuporn
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Article
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2005
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Journal of Heterocyclic Chemistry
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English
โ 65 KB
Reaction of 4,4,4-trifluoro-1-phenyl-1,3-butanedione with hydroxylamine led to the formation of 5hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole which was dehydrated to 3-phenyl-5-(trifluoromethyl)isoxazole. This isomer can also be synthesized by reaction of 4-chloro-4-phenyl-1,1,1-trifluo