Synthesis of peptides containing bis-imidazole ligands
✍ Scribed by Zsuzsanna Likó; Helga Süli-Vargha
- Book ID
- 103406319
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 240 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The reaction of aldimines with __α__‐(hydroxyimino) ketones of type **10** (1,2‐diketone monooximes) was used to prepare 2‐unsubstituted imidazole 3‐oxides **11** bearing an alkanol chain at N(1) (__Scheme 2, Table 1__). These products were transformed into the corresponding 2__H__‐imid
Novel 5-ring heterocyclic building blocks are synthesized. These can be incorporated into analogs of peptide antibiotics such as microcin B17, which is a potent DNA-gyrase inhibitor that exhibits eight thiazole and oxazole moieties. In particular, the syntheses of imidazole and bisoxazole amino acid