Synthesis of Pentasubstituted Pyridines from C-Alkyl-N,N-dialkylcyanoacetamides
✍ Scribed by A. L. Cossey; Dr. R. L. N. Harris; Dr. J. L. Huppatz; Dr. J. N. Phillips
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 202 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The reaction products of the addition of 1-(N,N-diethy1amine)prop-1-yne to N-vinylcarbodiimides and -ketenimines have been identified. Two pyridine regioisomers can be obtained under thermal control according to a 14 + 21 or 12 + 21 cycloaddition mechanism. At temperatures above 100°C a competing el
## Abstract **Three contiguous stereocenters** can be established with remarkable diastereoselectivity in a double Reformatsky sequence. Densely functionalized γ‐butyrolactones were assembled rapidly by this approach, in which a ketone is used as the terminal electrophile (see scheme). Secondary tr