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Synthesis of osseous specific 32P-labeled disodium ethane-1-hydroxy-1,1-diphosphonate

✍ Scribed by Lionel D. McCreary; Andrew J. Tofe; Marion D. Francis

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
337 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

High specific activity 32P-labeled disodium ethane-lhydroxy-1,l-diphosphonate has been prepared for specific use as a radiothera eutic ameliorative treatment of osseous tumors by reacting s2P-labeled phosphorus trichloride, acetic acid and water. This compound has been purified by crystallization of the disodium salt from a water-ethanol solution. Product identity and purity were established by reverse isotope dilution analysis. Spectrochemical quantitation, thin layer chromatography, radionuclide beta energy and half-life determinations are presented as essential procedures for establishing chemical and radiochemical purity when human distribution studies are planned.

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