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Synthesis of Organoselenium Sulfonamides as New Potential Cytokine Inducers: 2,2′-Diselenobis(benzenesulfonamides) and 1,3,2-Benzothiaselenazolone 1,1-Dioxides

✍ Scribed by Krystian Kloc; Jacek Mlochowski

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
118 KB
Volume
1999
Category
Article
ISSN
1434-193X

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✦ Synopsis

Keywords: 1,3,2-Benzothiaselenazole 1,1-dioxides / Cytokine inducers / Diselenobis(benzenesulfonamides) / Diselenides / Sulfonamides

A convenient method for the synthesis of 2,2Ј-diseleno-with ammonia or primary amines to give the sulfonamides 4.

Finally, cyclization of these sulfonamides by oxidation with bis(benzenesulfonamides) 4 and 2-substituted 1,3,2-benzothiaselenazole 1,1-dioxides 2, has been elaborated. It is benzoyl peroxide or by treatment of their sodium or potassium salt with elemental bromine produces 1,3,2-based on the conversion of 2-aminobenzenesulfonic acid into bis[2-(chlorosulfonyl)phenyl] diselenide (6), and reaction thiaselenazole 1,1-dioxides 2.

📜 SIMILAR VOLUMES

Synthesis and Properties of 2-Carboxyalk
Synthesis and Properties of 2-Carboxyalkyl-1,2-benzisoselenazol-3(2H)-ones and Related Organoselenium Compounds as Nitric Oxide Synthase Inhibitors and Cytokine Inducers
✍ Mlochowski, Jacek ;Juchniewicz, Leszek ;Kloc, Krystian ;Gryglewski, Ryszard J. ; 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 607 KB

## Abstract A convenient synthesis of the 2‐carboxyalkyl‐1,2‐benzisoselenazol‐3(2__H__)‐ones 4a–k and their esters 41–p from 2‐(chloroseleno)benzoyl chloride (2) and amino acids or their carboxy esters is reported. In similar way other 2‐substituted 1,2‐benzisoselenazol‐3(2__H__)‐ones 4q–u were syn