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Synthesis of Optically Pure 3,4-Disubstituted l -Glutamates from a Novel 2,3-Aziridino-γ-lactone 4-Carboxylate Derivative

✍ Scribed by Dauban, Philippe; Chiaroni, Angèle; Riche, Claude; Dodd, Robert H.


Book ID
126418484
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
406 KB
Volume
61
Category
Article
ISSN
0022-3263

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Enantiospecific synthesis of 3,4-disubst
✍ Zhaohua Yan; Robert Weaving; Philippe Dauban; Robert H. Dodd 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 265 KB

The preparation of enantiomerically pure 3,4-disubstituted glutamic acids is described starting from D-ribose. This preparation involved the use of a 2,3-aziridino-g-lactone whose reactivity towards nucleophiles could be efficiently controlled to allow selective functionalization at the b-position.