Synthesis of Optically Active Nine-Membered Ring Lactams by a Zwitterionic Aza-Claisen Reaction
โ Scribed by Michel Diederich; Dr. Udo Nubbemeyer
- Book ID
- 101555089
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 368 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0044-8249
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๐ SIMILAR VOLUMES
The aza-Claisen rearrangement of vinylpyrrolidines 1 yielded almost exclusively the trans-3,8-disubstituted nine-membered ring lactams 2 (TBS=tBuMe Si), independent of whether cis or trans isomers were used as starting materials. The conformation (which provided facial chirality) of the medium-sized
Starting from condensation of two iridoid synthons, (3S,8R)-benzyloxy-l-iriden-7-al and (3R)-7-chloro-l-iridene, cotylenol, one of the representative fusicoccane diterpenoids having 5-8-5-membered tricyclic carbon framework, is now synthesized for the first time via an eight-membered ring formation