Synthesis of optically active chiral shell dendrons
β Scribed by Denise M. Junge; Dominic V. McGrath
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 233 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
We present the preparation of a series of chiral dendrons, in which chiral subunits are placed in individual generational shells at increasing distances from the focal point, by a combination of convergent and divergent dendrimer synthesis methods. Analysis of chiroptical data suggests that these dendrons do not possess conformational order in solution.
π SIMILAR VOLUMES
The synthesis of the chiral tin bromides 1-4 and hydrides 5 -8 , containing the potentially bidentate, optically active 2- phenyl ligands, is reported. The tin hydrides 5-8, with the tin atom as the stereogenic centre, were isolated as diastereomeric mixtures with diastereomeric ratios of dr = 5050
Boron azaenolates 2 and 8 from the optically active chloromethyloxazolines 1 and 7 have been found to couple with ketones in a highly diastereoselective fashion, which depends markedly upon the geometry (Z) of the azaenolates and the nature of the ligands which are present on the boron atom, in good
## Abstract The reduction of dimenthyl ketophosphonates with sodium borohydride involves asymmetric induction at the Ξ±βcarbon atom, resulting in a small excess of the (R)βenantiomer of the Ξ±βhydroxyphosphonate formed. A higher ee purity was achieved if the reduction of chiral dimenthyl ketophosphon