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Synthesis of optically active 10-methoxy- and 10-hydroxyaporphines from apomorphine

โœ Scribed by Robert. J. Borgman


Book ID
112123477
Publisher
Journal of Heterocyclic Chemistry
Year
1975
Tongue
English
Weight
121 KB
Volume
12
Category
Article
ISSN
0022-152X

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Preparation of (R)-11-hydroxyaporphine d
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## Abstract A Regioselective synthesis of (__R__)โ€11โ€hydroxyaporphine 2 directly from (__R__)โ€10,11โ€dihydroxyaporphine ((__R__)โ€apomorphine, 1) is described for the first time. The isopropylidene ketal ring of 10,11โ€(isopropylโ€idenyldioxy)aporphine 5 obtained by the isopropylidenation of apomorphin