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Synthesis of O,O-Diphenyl N-trichlorogermanylpropiono-α-aminophosphonates

✍ Scribed by Qingmin Wang; Qiang Zeng; Zhi Chen

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
144 KB
Volume
10
Category
Article
ISSN
1042-7163

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✦ Synopsis

A variety of novel O,O-Diphenyl N-(trichlorogermanyl)propiono-␣-aminophosphonates were synthesized by the reaction of b-(trichlorogermanyl) propionyl chloride with diphenyl ␣-aminophosphonates in the presence of triethylamine. The structures of all of the products were confirmed by 1 H-NMR spectroscopy, elemental analyses, and IR spectroscopy. Data of 1 H-NMR and IR spectroscopic determinations indicated the title compounds to be pentacoordinated organogermanium compounds. The results of bioassay showed that some of the title compounds possess potential anticancer activity. ᭧ 1999

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