Synthesis of O,O-Diethyl N,N-Dichlorophosphor-amidate and its Use for the Preparation of β-Chloro Amines from Olefins

Neoglycopeptide Synthesis and Purificati

Neoglycopeptide Synthesis and Purification in Multi-gram Scale: Preparation of O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-Nα-fluoren-9-yl-methoxycarbonyl-hydroxyproline and Its Use in the Pilot-scale Synthesis of the Potent Analgesic Glycopeptide O1.5-β-D-galactopyranosyl[DMet2, Hyp5]enkephalinamide

✍ Josep Lluís Torres; Pere Clapés 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB 👁 2 views

The preparation of a beta-galactosylated hydroxyproline derivative and its use in the multi-gram solid-phase synthesis of the potent analgesic neoglycopeptide O1.5-beta-D-galactopyranosyl [D-Met2, Hyp5]enkephalinamide is described in this paper. The most closely related impurities have been identifi