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Synthesis of Oligosaccharide Fragments of Mannosylated Lipoarabinomannan Appropriately Functionalized for Neoglycoconjugate Preparation

✍ Scribed by Gadikota, Rajendrakumar Reddy; Callam, Christopher S.; Appelmelk, Ben J.; Lowary, Todd L.


Book ID
126575018
Publisher
Taylor and Francis Group
Year
2003
Tongue
English
Weight
943 KB
Volume
22
Category
Article
ISSN
0732-8303

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Synthesis of oligosaccharide fragments o
✍ Vinodhkumar Subramaniam; Todd L. Lowary πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 751 KB

The synthesis of three mannosyl-arabinosides 4-6 found as terminal epitopes of mannosylated lipoarabinomannan (ManLAM) from Mycobacterium tuberculosis is reported. A key step in the synthesis of the required protected octyl 13-D-arabinofuranoside derivative 7 involved glycosylation of octanol by 5-O