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Synthesis of O2,2'-anhydro-5,6-dihydro nucleosides

โœ Scribed by Hall, Charles M.; Slomp, George.; Mizsak, Steve A.; Taylor, Arlen J.


Book ID
126465838
Publisher
American Chemical Society
Year
1972
Tongue
English
Weight
500 KB
Volume
37
Category
Article
ISSN
0022-3263

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Chloride ion, derived from 2,3-dichloro-5,6-dicyanohydroquinone (DDHQ), was found to participate in opening of the 2,2'-anhydro bond of 5,6-dihydropyrimidine nucleosides, but not their 5,6unsaturated counterparts. The increased basicity of the nucleosidic nitrogen is believed to be a factor in this