A new method for ynolate synthesis via the cleavage of ester dianions has been developed. The key intermediates, ester dianions, generated from ct-bromocarboxylic acid ester enolates via lithiumhalogen exchange turned out to be so labile that they were cleaved rapidly to give ynolates.
Synthesis of o-halogenophenylacetylenes via the dianion of phenylacetylene (1)
β Scribed by H. Hommes; H.D. Verkruijsse; L. Brandsma
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 121 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The o-halogenophenylacetylenes o-iodophenylacetylene, o-bromophenylacetylene and o-chlorophenylacetylene can be prepared by regiospecific reaction of iodine, bromine, and hexachloroethane respectively with the dianion of phenylacetylene.
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