Synthesis of Nα-(fluoren-9-ylmethoxycarbonyl)-Nε-[(7-methoxycoumarin-4-yl)acetyl]-L-lysine for use in solid-phase synthesis of fluorogenic substrates

Rapid and efficient preparative purifica

Rapid and efficient preparative purification of building blocks suitable for solid-phase synthesis of neoglycopeptides: Synthesis and purification ofO-(2,3,4,6-tetra-O-acetyl-β-d- galactopyranosyl/glucopyranosyl)-Nα-fluoren-9-yl- methoxycarbonyl-hydroxyproline

✍ Josep Lluís Torres; Eugènia Pagans; Pere Clapés 📂 Article 📅 1996 🏛 Springer Netherlands 🌐 English ⚖ 504 KB

As part of scaling-up studies for the preparation of antinociceptive neoglycopeptides, the purification of appropriate glycosylated building blocks has been optimized. The synthesis and purification of O-(2,3,4,6-tetra-O-acetyl-13-D-ga~act~pyran~sy~g~uc~pyran~sy~)-N%flu~ren-9-y~-meth~xycarb~ny~-hydr