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Synthesis of Nucleotide Analogues with Pyridylphosphonate and Pyridylphosphono thio ate Internucleotide Linkages

✍ Scribed by Johansson, Tommy; Stawinski, Jacek


Book ID
127229964
Publisher
Taylor and Francis Group
Year
2002
Tongue
English
Weight
79 KB
Volume
177
Category
Article
ISSN
1042-6507

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A new type of nucleotide analogue with 4
✍ Annika Kers; Jacek StawiΕ„ski πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 261 KB

Suitably protected dithymidine H-phosphonates were quantitatively converted into the corresponding dinucleoside 4-pyridylphosphonates by treatment with 1,8diazabicylo[5.4.0]undec-7-ene (DBU) in the presence of trityl chloride in pyridine. The reaction was found to be stereospecific and proceeded, mo