A new type of nucleotide analogue with 4
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Annika Kers; Jacek StawiΕski
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Article
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1999
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Elsevier Science
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French
β 261 KB
Suitably protected dithymidine H-phosphonates were quantitatively converted into the corresponding dinucleoside 4-pyridylphosphonates by treatment with 1,8diazabicylo[5.4.0]undec-7-ene (DBU) in the presence of trityl chloride in pyridine. The reaction was found to be stereospecific and proceeded, mo