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Synthesis of Nucleic Acids

โœ Scribed by SMELLIE, R. M. S.


Book ID
109666236
Publisher
Nature Publishing Group
Year
1969
Tongue
English
Weight
137 KB
Volume
221
Category
Article
ISSN
0028-0836

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Peptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O-[benzotriazol-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc-protected PNA