Synthesis of novel vitamin C phosphodiesters: Stability and antioxidant activity

✍ Scribed by Kazuo Morisaki; Shoichiro Ozaki

• Book ID: 102995290
• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 879 KB
• Volume: 286
• Category: Article
• ISSN: 0008-6215
• DOI: 10.1016/0008-6215(96)00043-2

✦ Synopsis

A novel series of hybrid L-ascorbic acid (vitamin C) phosphodiesters linked at the C-2 hydroxyl group with other biologically active substances, namely myo-inositol, arbutin, 4-hydroxy-L-proline, and glycolic acid were synthesized, and their thermal stability and reducing activity against free radicals were estimated in vitro. All of the phosphodiesters exhibited high thermal stabilities; however, their antioxidant activities in vitro were generally lower than that of vitamin C.