An efficient synthesis of tetracyclic uracil derivatives (polycyclic pyrans) is achieved via domino Knoevenagel-hetero-Diels-Alder reactions of O-propargylated salicylaldehyde derivatives with 1,3-dimethylbarbituric acid in water as solvent in the presence of CuI. The products are formed in good yie
Synthesis of novel tetra- and pentacyclic benzosultam scaffolds via domino Knoevenagel hetero-Diels–Alder reactions in water
✍ Scribed by Mehdi Ghandi, Shahab Sheibani…
- Book ID
- 120737122
- Publisher
- Iranian Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 451 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1735-207X
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## Abstract An efficient synthesis of polycyclic indole derivatives is achieved __via__ domino __Knoevenagel__–hetero‐__Diels–Alder__ reaction of __O__‐acrylated salicylaldehyde derivatives with dihydroindole‐2‐thiones in H~2~O as solvent. The products are formed in good‐to‐excellent yields with hi
An efficient synthesis of pentacyclic indole derivatives is achieved via domino Knoevenagel-hetero-Diels-Alder reactions of indolin-2-thiones and O-propargylated salicylaldehyde derivatives in CH 3 CN in the presence of 10 mol % of ZnO as a heterogeneous catalyst. The products are formed in good to