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Synthesis of Novel Taxoid Analogue Containing Sulfur Group on C-13 Side-Chain: 2′-Deoxy-2′-epi-mercaptopaclitaxel (I).

✍ Scribed by Xin Qi; Sang-Hyeup Lee; Juyoung Yoon; Yoon-Sik Lee

Publisher
John Wiley and Sons
Year
2004
Weight
83 KB
Volume
35
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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Synthesis of novel taxoid analogue conta
Synthesis of novel taxoid analogue containing sulfur group on C-13 side-chain: 2′-deoxy-2′-epi-mercaptopaclitaxel
✍ Xin Qi; Sang-Hyeup Lee; Juyoung Yoon; Yoon-Sik Lee 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 124 KB

Paclitaxel analogues with a thiol group in place of the hydroxyl group on the C-13 side-chain constitute an interesting avenue of research for the study of new taxoid compounds. A synthetic route for the preparation of 2 0 -deoxy-2 0 -epi-mercaptopaclitaxel with high ee has been developed. The key s