Synthesis of Novel Substituted Tetrazoles Having Antifungal Activity.
โ Scribed by Ram Shankar Upadhayaya; Sanjay Jain; Neelima Sinha; Nawal Kishore; Ramesh Chandra; Sudershan K. Arora
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 24 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Abstract
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Novel Synthesis of 5-Substituted Tetrazoles from Nitriles. -The reaction of nitriles (I) with sodium azide in the presence of an amine salt represents a new method for the preparation of 5-substituted tetrazoles (II) in high yields and purity. -(KOGURO, K.;
Synthesis and Antifungal Activity of Novel Thiazole-Containing Triazole Antifungals. -A series of new thiazole-containing triazole (IV), (X), (XI), and (XII) antifungals is synthesized on a route shown for the derivatives (IV). A detailed structure-activity relationship study is presented to elucid