Synthesis of Novel Structurally Simplified Estrogen Analogues
✍ Scribed by Lutz F. Tietze; Carsten A. Vock; Ilga K. Krimmelbein; J. Matthias Wiegand; Linda Nacke; Tokala Ramachandar; Kazi M. D. Islam; Christiane Gatz
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 360 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0947-6539
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The stereoselective synthesis of structurally simplified heptacyclic cephalostatin analogues 2, 3, 18-21, 31, 32 and 33 by multiple Heck reactions is described. The key step of the synthesis is a selective Heck reaction of hydrindene 7 with 12 and 25, respectively at the vinyl bromide moiety followe
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