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Synthesis of novel sila-substituted β-amino acids

✍ Scribed by Jennifer L Matthews; Duncan R McArthur; Kenneth W Muir

Book ID
104251501
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
125 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A highly efficient and stereoselective synthesis of unnatural cyclic sila-substituted b-amino acids has been developed from simple starting materials. The key step is nucleophilic ring opening of an intermediate aziridine with an umpolung synthon for the carboxylate anion. Functional group manipulation and deprotection reactions allow access to the desired trans b-amino acids.

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ChemInform Abstract: Enantioselective Sy
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✍ Claude Agami; Sandrine Cheramy; Luc Dechoux; Mohand Melaimi 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

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